Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting
Identifieur interne : 001208 ( Main/Exploration ); précédent : 001207; suivant : 001209Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting
Auteurs : Deepak Kilari [États-Unis] ; Enrique Soto-Perez-De-Celis [Mexique] ; Supriya Gupta Mohile [États-Unis] ; Shabbir M. H. Alibhai [Canada] ; Carolyn J. Presley [États-Unis] ; Tanya M. Wildes [États-Unis] ; Heidi D. Klepin [États-Unis] ; Wendy Demark-Wahnefried [États-Unis] ; Amina Jatoi [États-Unis] ; Robert Harrison [États-Unis] ; Elizabeth Won [États-Unis] ; Karen M. Mustian [États-Unis]Source :
- Journal of geriatric oncology [ 1879-4068 ] ; 2016.
Abstract
Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions.
Url:
DOI: 10.1016/j.jgo.2016.04.007
PubMed: 27197916
PubMed Central: 4969104
Affiliations:
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H." last="Alibhai">Shabbir M. H. Alibhai</name><affiliation wicri:level="1"><nlm:aff id="A4">University Health Network and University of Toronto, Department of Medicine, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network and University of Toronto, Department of Medicine, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Presley, Carolyn J" sort="Presley, Carolyn J" uniqKey="Presley C" first="Carolyn J." last="Presley">Carolyn J. Presley</name><affiliation wicri:level="1"><nlm:aff id="A5">Yale School of Medicine, Yale Cancer Center, Department of Medicine, Division of Medical Oncology, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Medicine, Yale Cancer Center, Department of Medicine, Division of Medical Oncology, New Haven, CT</wicri:regionArea><wicri:noRegion>CT</wicri:noRegion></affiliation></author><author><name sortKey="Wildes, Tanya M" sort="Wildes, Tanya M" uniqKey="Wildes T" first="Tanya M." last="Wildes">Tanya M. Wildes</name><affiliation wicri:level="1"><nlm:aff id="A6">Washington University, Department of Medicine, Division of Medical Oncology, St. Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University, Department of Medicine, Division of Medical Oncology, St. Louis, MO</wicri:regionArea><wicri:noRegion>MO</wicri:noRegion></affiliation></author><author><name sortKey="Klepin, Heidi D" sort="Klepin, Heidi D" uniqKey="Klepin H" first="Heidi D." last="Klepin">Heidi D. Klepin</name><affiliation wicri:level="1"><nlm:aff id="A7">Wake Forrest School of Medicine, Department of Medicine, Section of Hematology and Oncology, Winston-Salem, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wake Forrest School of Medicine, Department of Medicine, Section of Hematology and Oncology, Winston-Salem, NC</wicri:regionArea><wicri:noRegion>NC</wicri:noRegion></affiliation></author><author><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name><affiliation wicri:level="1"><nlm:aff id="A8">University of Alabama at Birmingham Comprehensive Cancer Center, Division of Cancer Control and Prevention, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham Comprehensive Cancer Center, Division of Cancer Control and Prevention, Birmingham, AL</wicri:regionArea><wicri:noRegion>AL</wicri:noRegion></affiliation></author><author><name sortKey="Jatoi, Amina" sort="Jatoi, Amina" uniqKey="Jatoi A" first="Amina" last="Jatoi">Amina Jatoi</name><affiliation wicri:level="1"><nlm:aff id="A9">Mayo Clinic, Department of Oncology, Division of Medical Oncology, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Department of Oncology, Division of Medical Oncology, Rochester, MN</wicri:regionArea><wicri:noRegion>MN</wicri:noRegion></affiliation></author><author><name sortKey="Harrison, Robert" sort="Harrison, Robert" uniqKey="Harrison R" first="Robert" last="Harrison">Robert Harrison</name><affiliation wicri:level="1"><nlm:aff id="A10">University of Rochester Medical Center, SCOREboard, Rochester, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Medical Center, SCOREboard, Rochester, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author><author><name sortKey="Won, Elizabeth" sort="Won, Elizabeth" uniqKey="Won E" first="Elizabeth" last="Won">Elizabeth Won</name><affiliation wicri:level="1"><nlm:aff id="A11">Memorial Sloan-Kettering Cancer Center, Department of Medicine, Division of Medical Oncology, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan-Kettering Cancer Center, Department of Medicine, Division of Medical Oncology, New York, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author><author><name sortKey="Mustian, Karen M" sort="Mustian, Karen M" uniqKey="Mustian K" first="Karen M." last="Mustian">Karen M. Mustian</name><affiliation wicri:level="1"><nlm:aff id="A12">University of Rochester Medical Center, Wilmot Cancer Institute, Department of Surgery, Division of Cancer Control, Rochester, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Medical Center, Wilmot Cancer Institute, Department of Surgery, Division of Cancer Control, Rochester, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of geriatric oncology</title><idno type="ISSN">1879-4068</idno><idno type="eISSN">1879-4076</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>Mexique</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kilari, Deepak" sort="Kilari, Deepak" uniqKey="Kilari D" first="Deepak" last="Kilari">Deepak Kilari</name></noRegion><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name><name sortKey="Harrison, Robert" sort="Harrison, Robert" uniqKey="Harrison R" first="Robert" last="Harrison">Robert Harrison</name><name sortKey="Jatoi, Amina" sort="Jatoi, Amina" uniqKey="Jatoi A" first="Amina" last="Jatoi">Amina Jatoi</name><name sortKey="Klepin, Heidi D" sort="Klepin, Heidi D" uniqKey="Klepin H" first="Heidi D." last="Klepin">Heidi D. Klepin</name><name sortKey="Mohile, Supriya Gupta" sort="Mohile, Supriya Gupta" uniqKey="Mohile S" first="Supriya Gupta" last="Mohile">Supriya Gupta Mohile</name><name sortKey="Mustian, Karen M" sort="Mustian, Karen M" uniqKey="Mustian K" first="Karen M." last="Mustian">Karen M. Mustian</name><name sortKey="Presley, Carolyn J" sort="Presley, Carolyn J" uniqKey="Presley C" first="Carolyn J." last="Presley">Carolyn J. Presley</name><name sortKey="Wildes, Tanya M" sort="Wildes, Tanya M" uniqKey="Wildes T" first="Tanya M." last="Wildes">Tanya M. Wildes</name><name sortKey="Won, Elizabeth" sort="Won, Elizabeth" uniqKey="Won E" first="Elizabeth" last="Won">Elizabeth Won</name></country><country name="Mexique"><noRegion><name sortKey="Soto Perez De Celis, Enrique" sort="Soto Perez De Celis, Enrique" uniqKey="Soto Perez De Celis E" first="Enrique" last="Soto-Perez-De-Celis">Enrique Soto-Perez-De-Celis</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Alibhai, Shabbir M H" sort="Alibhai, Shabbir M H" uniqKey="Alibhai S" first="Shabbir M. H." last="Alibhai">Shabbir M. H. Alibhai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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